IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
IL-1 causes a marked increase in the degree of expansion of naïve and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1β, is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in IL-1R1⁻/⁻ recipients, I...
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Full title
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
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TN_cdi_proquest_journals_201420744
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201420744
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0902745106
