The pH-altering agent omeprazole affects rate but not the extent of ibrutinib exposure
The pH-altering agent omeprazole affects rate but not the extent of ibrutinib exposure
About this item
Full title
Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Purpose
This drug-interaction study evaluated the effect of omeprazole, a proton-pump inhibitor, on ibrutinib’s pharmacokinetics (PK) in healthy participants.
Methods
This open-label, sequential-design study included 20 healthy adults aged 18–55 years. Ibrutinib (560 mg, single dose) was administered after an overnight fast alone on day 1...
Alternative Titles
Full title
The pH-altering agent omeprazole affects rate but not the extent of ibrutinib exposure
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2051405553
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2051405553
Other Identifiers
ISSN
0344-5704
E-ISSN
1432-0843
DOI
10.1007/s00280-018-3613-9
