Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramm...
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
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Full title
Author / Creator
Patra, Krushna C. , Kato, Yasutaka , Mizukami, Yusuke , Widholz, Sebastian , Boukhali, Myriam , Revenco, Iulia , Grossman, Elizabeth A. , Ji, Fei , Sadreyev, Ruslan I. , Liss, Andrew S. , Screaton, Robert A. , Sakamoto, Kei , Ryan, David P. , Mino-Kenudson, Mari , Castillo, Carlos Fernandez-del , Nomura, Daniel K. , Haas, Wilhelm and Bardeesy, Nabeel
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
G protein
α
s
(GNAS) mediates receptor-stimulated cAMP signalling, which integrates diverse environmental cues with intracellular responses.
GNAS
is mutationally activated in multiple tumour types, although its oncogenic mechanisms remain elusive. We explored this question in pancreatic tumourigenesis where concurrent
GNAS
and<...
Alternative Titles
Full title
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
Authors, Artists and Contributors
Author / Creator
Kato, Yasutaka
Mizukami, Yusuke
Widholz, Sebastian
Boukhali, Myriam
Revenco, Iulia
Grossman, Elizabeth A.
Ji, Fei
Sadreyev, Ruslan I.
Liss, Andrew S.
Screaton, Robert A.
Sakamoto, Kei
Ryan, David P.
Mino-Kenudson, Mari
Castillo, Carlos Fernandez-del
Nomura, Daniel K.
Haas, Wilhelm
Bardeesy, Nabeel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2063263239
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2063263239
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-018-0122-3
