p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
About this item
Full title
Author / Creator
Ihry, Robert J. , Worringer, Kathleen A. , Salick, Max R. , Frias, Elizabeth , Ho, Daniel , Theriault, Kraig , Kommineni, Sravya , Chen, Julie , Sondey, Marie , Ye, Chaoyang , Randhawa, Ranjit , Kulkarni, Tripti , Yang, Zinger , McAllister, Gregory , Russ, Carsten , Reece-Hoyes, John , Forrester, William , Hoffman, Gregory R. , Dolmetsch, Ricardo and Kaykas, Ajamete
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-wide screens in human cells
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–
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. Whereas some cell types are amenable to genome engineering, genomes of human pluripotent stem cells (hPSCs) have been difficult to engineer, with reduced efficiencies relative to tumour cell lines or mouse embryonic stem...
Alternative Titles
Full title
p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
Authors, Artists and Contributors
Author / Creator
Worringer, Kathleen A.
Salick, Max R.
Frias, Elizabeth
Ho, Daniel
Theriault, Kraig
Kommineni, Sravya
Chen, Julie
Sondey, Marie
Ye, Chaoyang
Randhawa, Ranjit
Kulkarni, Tripti
Yang, Zinger
McAllister, Gregory
Russ, Carsten
Reece-Hoyes, John
Forrester, William
Hoffman, Gregory R.
Dolmetsch, Ricardo
Kaykas, Ajamete
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2067108382
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2067108382
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-018-0050-6
