The Dimer-dependent Catalytic Activity of RAF Family Kinases Is Revealed Through Characterizing Thei...
The Dimer-dependent Catalytic Activity of RAF Family Kinases Is Revealed Through Characterizing Their Oncogenic Mutants
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Although extensively studied for three decades, the molecular mechanisms that regulate the RAF/MEK/ERK kinase cascade remain ambiguous. Recent studies identified the dimerization of RAF as a key event in the activation of this cascade. Here, we show that in-frame deletions in the 3- C loop activate ARAF as well as BRAF and other oncogenic kinases b...
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The Dimer-dependent Catalytic Activity of RAF Family Kinases Is Revealed Through Characterizing Their Oncogenic Mutants
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TN_cdi_proquest_journals_2068568484
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2068568484
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E-ISSN
2692-8205
DOI
10.1101/338293
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https://www.proquest.com/docview/2068568484?pq-origsite=primo&accountid=13902
