MDM4 is an essential disease driver targeted by 1q gain in Burkitt lymphoma
MDM4 is an essential disease driver targeted by 1q gain in Burkitt lymphoma
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Author / Creator
Huellein, Jennifer , Slabicki, Mikolaj , Rosolowski, Maciej , Jethwa, Alexander , Habringer, Stefan , Tomska, Katarzyna , Kurilov, Roma , Lu, Junyan , Scheinost, Sebastian , Wagener, Rabea , Huang, Zhiqin , Lukas, Marina , Yavorska, Olena , Helferich, Hanne , Scholtysik, Rene , Bonneau, Kyle , Tedesco, Donato , Kueppers, Ralf , Klapper, Wolfram , Pott, Christiane , Stilgenbauer, Stephan , Burkhardt, Birgit , Loeffler, Markus , Truemper, Lorenz , Hummel, Michael , Brors, Benedikt , Zapatka, Marc , Siebert, Reiner , Keller, Ulrich , Huber, Wolfgang , Kreuz, Markus , Zenz, Thorsten and Consortium, Mmml
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
Oncogenic MYC activation promotes cellular proliferation in Burkitt lymphoma (BL), but also induces cell cycle arrest and apoptosis mediated by TP53, a tumor suppressor gene that is mutated in 40% of BL cases. To identify therapeutic targets in BL, we investigated molecular dependencies in BL cell lines using RNAi-based, loss-of-function screening....
Alternative Titles
Full title
MDM4 is an essential disease driver targeted by 1q gain in Burkitt lymphoma
Authors, Artists and Contributors
Author / Creator
Slabicki, Mikolaj
Rosolowski, Maciej
Jethwa, Alexander
Habringer, Stefan
Tomska, Katarzyna
Kurilov, Roma
Lu, Junyan
Scheinost, Sebastian
Wagener, Rabea
Huang, Zhiqin
Lukas, Marina
Yavorska, Olena
Helferich, Hanne
Scholtysik, Rene
Bonneau, Kyle
Tedesco, Donato
Kueppers, Ralf
Klapper, Wolfram
Pott, Christiane
Stilgenbauer, Stephan
Burkhardt, Birgit
Loeffler, Markus
Truemper, Lorenz
Hummel, Michael
Brors, Benedikt
Zapatka, Marc
Siebert, Reiner
Keller, Ulrich
Huber, Wolfgang
Kreuz, Markus
Zenz, Thorsten
Consortium, Mmml
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2068829500
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2068829500
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/289363
How to access this item
https://www.proquest.com/docview/2068829500?pq-origsite=primo&accountid=13902
