Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities
Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities
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Author / Creator
Adrian Constantin Apetri , Crespo, Rosa , Juraszek, Jarek , Pascual, Gabriel , Janson, Roosmarijn , Zhu, Xueyong , Keogh, Elissa , Zhang, Heng , Holland, Trevin , Wadia, Jay , Verveen, Hanneke , Siregar, Berdien , Mrosek, Michael , Taggenbrock, Renske , Jeroen Van Ameijde , Inganas, Hanna , Margot Van Winsen , Koldijk, Martin , Zuijdgeest, David , Borgers, Marianne , Dockx, Koen , Stoop, Esther , Yu, Wenli , Els C Brinkman-Van Der Linden , Ummenthum, Kimberley , Kristof Van Kolen , Mercken, Marc , Steinbacher, Stefan , De Marco, Donata , Hoozemans, Jeroen J , Wilson, Ian A , Koudstaal, Wouter and Goudsmit, Jaap
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG+ memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated VH5-51/VL4-1 antibodies. One of these, CBTAU-27.1, binds to the aggregation motif in the R3 repeat do...
Alternative Titles
Full title
Common antigenic motif recognized by human VH5-51/VL4-1 tau antibodies with distinct functionalities
Authors, Artists and Contributors
Author / Creator
Crespo, Rosa
Juraszek, Jarek
Pascual, Gabriel
Janson, Roosmarijn
Zhu, Xueyong
Keogh, Elissa
Zhang, Heng
Holland, Trevin
Wadia, Jay
Verveen, Hanneke
Siregar, Berdien
Mrosek, Michael
Taggenbrock, Renske
Jeroen Van Ameijde
Inganas, Hanna
Margot Van Winsen
Koldijk, Martin
Zuijdgeest, David
Borgers, Marianne
Dockx, Koen
Stoop, Esther
Yu, Wenli
Els C Brinkman-Van Der Linden
Ummenthum, Kimberley
Kristof Van Kolen
Mercken, Marc
Steinbacher, Stefan
De Marco, Donata
Hoozemans, Jeroen J
Wilson, Ian A
Koudstaal, Wouter
Goudsmit, Jaap
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2068979279
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2068979279
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/287003
How to access this item
https://www.proquest.com/docview/2068979279?pq-origsite=primo&accountid=13902
