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Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer's di...

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer's di...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2089005086

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer's disease

About this item

Full title

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer's disease

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2018-08

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

One of the key knowledge gaps blocking development of effective therapeutics for Alzheimer's disease (AD) is the lack of understanding of how amyloid beta (A ) and tau cooperate in causing disease phenotypes. Within a mouse tau deficient background, we probed the molecular, cellular and behavioural disruption triggered by wild-type human tau's infl...

Alternative Titles

Full title

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer's disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2089005086

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2089005086

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/393405