Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse mod...
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model
About this item
Full title
Author / Creator
Choi, Se Hoon , Bylykbashi, Enjana , Chatila, Zena K , Lee, Star W , Pulli, Benjamin , Clemenson, Gregory D , Kim, Eunhee , Rompala, Alexander , Oram, Mary K , Asselin, Caroline , Aronson, Jenna , Zhang, Can , Miller, Sean J , Lesinski, Andrea , Chen, John W , Kim, Doo Yeon , van Praag, Henriette , Spiegelman, Bruce M , Gage, Fred H and Tanzi, Rudolph E
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: The American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer's disease (AD) pathology. We found that exercise provided cognitive benefit to 5×FAD mice, a mouse model of AD, by inducing AHN and elevating levels of brain-derived neurotrophic factor (BDNF). Neither stimulation of AHN alone, nor exercise, in the absence of increased A...
Alternative Titles
Full title
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model
Authors, Artists and Contributors
Author / Creator
Bylykbashi, Enjana
Chatila, Zena K
Lee, Star W
Pulli, Benjamin
Clemenson, Gregory D
Kim, Eunhee
Rompala, Alexander
Oram, Mary K
Asselin, Caroline
Aronson, Jenna
Zhang, Can
Miller, Sean J
Lesinski, Andrea
Chen, John W
Kim, Doo Yeon
van Praag, Henriette
Spiegelman, Bruce M
Gage, Fred H
Tanzi, Rudolph E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2100390451
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2100390451
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aan8821
