The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau
The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Tau pathology is characterized as a form of frontotemporal lobar degeneration (FTLD) known as FTLD-tau. The underlying pathogenic mechanisms are not known and no therapeutic interventions are currently available. Here, we report that the neurotrophin receptor p75NTR plays a critical role in the pathogenesis of FTLD-tau. The expression of p75NTR and...
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Full title
The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau
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TN_cdi_proquest_journals_2111724640
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2111724640
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ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-018-0071-z
