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APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE M...

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE M...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2139373313

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

About this item

Full title

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2018-12

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

The epsilon-4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset Alzheimers disease (AD). However, the reason for the association between APOE4 and AD remains unclear. While much of the research has focused on the ability of the apoE4 protein to increase the aggregation and decrease the clearance of amyloid beta, t...

Alternative Titles

Full title

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2139373313

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2139373313

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/482422