Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
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Author / Creator
Li, Yingfeng , Zhang, Zhuqiang , Chen, Jiayu , Liu, Wenqiang , Lai, Weiyi , Liu, Baodong , Li, Xiang , Liu, Liping , Xu, Shaohua , Dong, Qiang , Wang, Mingzhu , Duan, Xiaoya , Tan, Jiajun , Zheng, Yong , Zhang, Pumin , Fan, Guoping , Wong, Jiemin , Xu, Guo-Liang , Wang, Zhigao , Wang, Hailin , Gao, Shaorong and Zhu, Bing
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA methylation, which is predominantly mediated by DNMT3A, a de novo DNA methyltransferase
1
,
2
. Unlike the genome of sperm and most somatic cells, the oocyte genome is hypomethylated in transcriptionally inert regions
2
–
4
. However, how such...
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Full title
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
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TN_cdi_proquest_journals_2160706990
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2160706990
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0751-5
