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Interleukin-1[beta] inhibits ATP-induced protein kinase B activation in renal mesangial cells by two...

Interleukin-1[beta] inhibits ATP-induced protein kinase B activation in renal mesangial cells by two...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_217196637

Interleukin-1[beta] inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide

About this item

Full title

Interleukin-1[beta] inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide

Publisher

London: Blackwell Publishing Ltd

Journal title

British journal of pharmacology, 2003-02, Vol.138 (3), p.461

Language

English

Formats

Publication information

Publisher

London: Blackwell Publishing Ltd

More information

Scope and Contents

Contents

1 Extracellular nucleotides, like ATP and UTP, have been shown to activate the protein kinase B (PKB) pathway in mesangial cells. In this study we report that the pro-inflammatory cytokine interleukin-1beta (IL-1beta) inhibits ATP-induced PKB activation. 2 Pretreatment of mesangial cells with IL-1beta leads to a time-dependent decrease of ATP-induc...

Alternative Titles

Full title

Interleukin-1[beta] inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_217196637

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_217196637

Other Identifiers

ISSN

0007-1188

E-ISSN

1476-5381

DOI

10.1038/sj.bjp.0705064

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