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Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2186152570

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

About this item

Full title

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

Publisher

New York: Elsevier Inc

Journal title

Laboratory investigation, 2019-03, Vol.99 (3), p.346-357

Language

English

Formats

Publication information

Publisher

New York: Elsevier Inc

More information

Scope and Contents

Contents

Trimethylamine N-oxide (TMAO), a gut microbe-derived metabolite of dietary choline and other trimethylamine-containing nutrients, has been linked to increased cardiovascular disease risk. It is unknown whether TMAO plays a role in the development of cardiac hypertrophy. Transverse aortic constriction (TAC) was performed to induce cardiac hypertroph...

Alternative Titles

Full title

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2186152570

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2186152570

Other Identifiers

ISSN

0023-6837

E-ISSN

1530-0307

DOI

10.1038/s41374-018-0091-y

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