Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
About this item
Full title
Author / Creator
Junutula, Jagath R , Raab, Helga , Clark, Suzanna , Bhakta, Sunil , Leipold, Douglas D , Weir, Sylvia , Chen, Yvonne , Simpson, Michelle , Tsai, Siao Ping , Dennis, Mark S , Lu, Yanmei , Meng, Y Gloria , Ng, Carl , Yang, Jihong , Lee, Chien C , Duenas, Eileen , Gorrell, Jeffrey , Katta, Viswanatham , Kim, Amy , McDorman, Kevin , Flagella, Kelly , Venook, Rayna , Ross, Sarajane , Spencer, Susan D , Lee Wong, Wai , Lowman, Henry B , Vandlen, Richard , Sliwkowski, Mark X , Scheller, Richard H , Polakis, Paul and Mallet, William
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Systemic toxicity associated with heterogeneity in the stoichiometries and sites of drug attachment is a major hurdle to developing antibody-drug conjugates (ADCs) for cancer therapy. Junutula
et al
. engineer cysteine residues in constant domains to produce near-homogenous ADCs that are better tolerated than conventional ADCs, without any lo...
Alternative Titles
Full title
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Authors, Artists and Contributors
Author / Creator
Raab, Helga
Clark, Suzanna
Bhakta, Sunil
Leipold, Douglas D
Weir, Sylvia
Chen, Yvonne
Simpson, Michelle
Tsai, Siao Ping
Dennis, Mark S
Lu, Yanmei
Meng, Y Gloria
Ng, Carl
Yang, Jihong
Lee, Chien C
Duenas, Eileen
Gorrell, Jeffrey
Katta, Viswanatham
Kim, Amy
McDorman, Kevin
Flagella, Kelly
Venook, Rayna
Ross, Sarajane
Spencer, Susan D
Lee Wong, Wai
Lowman, Henry B
Vandlen, Richard
Sliwkowski, Mark X
Scheller, Richard H
Polakis, Paul
Mallet, William
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_222233892
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_222233892
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.1480
