Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondr...
Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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During the early stages of Alzheimer's disease (AD) in both mouse models and human patients, soluble forms of Amyloidβ1-42 oligomers (Aβ42o) trigger loss of excitatory synapses (synaptotoxicity) in cortical and hippocampal pyramidal neurons (PNs) prior to the formation of insoluble Aβ plaques. We observed a spatially restricted structural remodelin...
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Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
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TN_cdi_proquest_journals_2224739598
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2224739598
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2692-8205
DOI
10.1101/637199
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https://www.proquest.com/docview/2224739598?pq-origsite=primo&accountid=13902
