The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also critical for the generation of interleukin 17–producing T helper cells (T
H
-17 cells), which are associated with experimental autoimmune encephalomyelitis. IRF4-deficient (
Irf4
−/−
) mice did not develop e...
Alternative Titles
Full title
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
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TN_cdi_proquest_journals_222739151
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_222739151
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni1500
