Targeted depletion of lymphotoxin-[alpha]-expressing TH1 and TH17 cells inhibits autoimmune disease
Targeted depletion of lymphotoxin-[alpha]-expressing TH1 and TH17 cells inhibits autoimmune disease
About this item
Full title
Author / Creator
Chiang, Eugene Y , Kolumam, Ganesh A , Yu, Xin , Francesco, Michelle , Ivelja, Sinisa , Peng, Ivan , Gribling, Peter , Shu, Jean , Lee, Wyne P , Refino, Canio J , Balazs, Mercedesz , Paler-martinez, Andres , Nguyen, Allen , Young, Judy , Barck, Kai H , Carano, Richard A D , Ferrando, Ron , Diehl, Lauri , Chatterjea, Devavani and Grogan, Jane L
Publisher
New York: Nature Publishing Group
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group
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More information
Scope and Contents
Contents
Uncontrolled T helper type 1 (T(H)1) and T(H)17 cells are associated with autoimmune responses. We identify surface lymphotoxin-alpha (LT-alpha) as common to T(H)0, T(H)1 and T(H)17 cells and employ a unique strategy to target these subsets using a depleting monoclonal antibody (mAb) directed to surface LT-alpha. Depleting LT-alpha-specific mAb inh...
Alternative Titles
Full title
Targeted depletion of lymphotoxin-[alpha]-expressing TH1 and TH17 cells inhibits autoimmune disease
Authors, Artists and Contributors
Author / Creator
Kolumam, Ganesh A
Yu, Xin
Francesco, Michelle
Ivelja, Sinisa
Peng, Ivan
Gribling, Peter
Shu, Jean
Lee, Wyne P
Refino, Canio J
Balazs, Mercedesz
Paler-martinez, Andres
Nguyen, Allen
Young, Judy
Barck, Kai H
Carano, Richard A D
Ferrando, Ron
Diehl, Lauri
Chatterjea, Devavani
Grogan, Jane L
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_223110618
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_223110618
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.1984
