Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung can...
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
About this item
Full title
Author / Creator
Engelman, Jeffrey A , Chen, Liang , Tan, Xiaohong , Crosby, Katherine , Guimaraes, Alexander R , Upadhyay, Rabi , Maira, Michel , McNamara, Kate , Perera, Samanthi A , Song, Youngchul , Chirieac, Lucian R , Kaur, Ramneet , Lightbown, Angela , Simendinger, Jessica , Li, Timothy , Padera, Robert F , García-Echeverría, Carlos , Weissleder, Ralph , Mahmood, Umar , Cantley, Lewis C and Wong, Kwok-Kin
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Inhibitors of PI3 kinase are in development for the treatment of cancer. But whether these compounds will work as single agents remains to be seen. Engelman
et al
. now show that a PI3K-mTOR inhibitor is effective in a mouse model of lung cancer induced by a mutant
PIK3CA
but has no effect on
Kras
-induced tumors. Combining the PI...
Alternative Titles
Full title
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Authors, Artists and Contributors
Author / Creator
Chen, Liang
Tan, Xiaohong
Crosby, Katherine
Guimaraes, Alexander R
Upadhyay, Rabi
Maira, Michel
McNamara, Kate
Perera, Samanthi A
Song, Youngchul
Chirieac, Lucian R
Kaur, Ramneet
Lightbown, Angela
Simendinger, Jessica
Li, Timothy
Padera, Robert F
García-Echeverría, Carlos
Weissleder, Ralph
Mahmood, Umar
Cantley, Lewis C
Wong, Kwok-Kin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_223113561
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_223113561
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.1890
