Somatostatin regulates brain amyloid [beta] peptide A[beta]42 through modulation of proteolytic degr...
Somatostatin regulates brain amyloid [beta] peptide A[beta]42 through modulation of proteolytic degradation
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Publisher
New York: Nature Publishing Group
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Language
English
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New York: Nature Publishing Group
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Contents
Expression of somatostatin in the brain declines during aging in various mammals including apes and humans. A prominent decrease in this neuropeptide also represents a pathological characteristic of Alzheimer disease. Using in vitro and in vivo paradigms, we show that somatostatin regulates the metabolism of amyloid beta peptide (Abeta), the primar...
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Somatostatin regulates brain amyloid [beta] peptide A[beta]42 through modulation of proteolytic degradation
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TN_cdi_proquest_journals_223122451
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_223122451
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm1206
