Rapid identification of functionally critical amino acids in a G protein–coupled receptor
Rapid identification of functionally critical amino acids in a G protein–coupled receptor
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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G protein–coupled receptors (GPCRs) comprise one of the largest protein families found in nature. Here we describe a new experimental strategy that allows rapid identification of functionally critical amino acids in the rat M
3
muscarinic acetylcholine receptor (M3R), a prototypic class I GPCR. This approach involves low-frequency random muta...
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Full title
Rapid identification of functionally critical amino acids in a G protein–coupled receptor
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TN_cdi_proquest_journals_223257567
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_223257567
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/nmeth990
