Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy
Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy
About this item
Full title
Author / Creator
Perez-Ruiz, Elisabeth , Minute, Luna , Otano, Itziar , Alvarez, Maite , Ochoa, Maria Carmen , Belsue, Virginia , de Andrea, Carlos , Rodriguez-Ruiz, Maria Esperanza , Perez-Gracia, Jose Luis , Marquez-Rodas, Ivan , Llacer, Casilda , Alvarez, Martina , de Luque, Vanesa , Molina, Carmen , Teijeira, Alvaro , Berraondo, Pedro and Melero, Ignacio
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer
1
–
3
. However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended dose of ipilimumab that is given to pati...
Alternative Titles
Full title
Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy
Authors, Artists and Contributors
Author / Creator
Minute, Luna
Otano, Itziar
Alvarez, Maite
Ochoa, Maria Carmen
Belsue, Virginia
de Andrea, Carlos
Rodriguez-Ruiz, Maria Esperanza
Perez-Gracia, Jose Luis
Marquez-Rodas, Ivan
Llacer, Casilda
Alvarez, Martina
de Luque, Vanesa
Molina, Carmen
Teijeira, Alvaro
Berraondo, Pedro
Melero, Ignacio
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2233946635
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2233946635
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1162-y
