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Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury...

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2239633177

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation

About this item

Full title

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation

Publisher

New York: Elsevier Inc

Journal title

Laboratory investigation, 2019-06, Vol.99 (6), p.793-806

Language

English

Formats

Publication information

Publisher

New York: Elsevier Inc

More information

Scope and Contents

Contents

Although inhibition of epidermal growth factor receptor (EGFR)-mediated cell signaling by the EGFR tyrosine kinase inhibitor gefitinib is highly effective against advanced non-small cell lung cancer, this drug might promote severe acute interstitial pneumonia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive...

Alternative Titles

Full title

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2239633177

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2239633177

Other Identifiers

ISSN

0023-6837

E-ISSN

1530-0307

DOI

10.1038/s41374-019-0187-z

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