Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the assembly and activation of the NLRP3 inflammasome in interphase. Here we report a cryo-electron microscopy structure of inactive human NLRP3 in complex with NEK7, at a resolutio...
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Full title
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
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TN_cdi_proquest_journals_2250921012
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2250921012
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1295-z
