Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
About this item
Full title
Author / Creator
Zhou, Changyang , Sun, Yidi , Yan, Rui , Liu, Yajing , Zuo, Erwei , Gu, Chan , Han, Linxiao , Wei, Yu , Hu, Xinde , Zeng, Rong , Li, Yixue , Zhou, Haibo , Guo, Fan and Yang, Hui
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Recently developed DNA base editing methods enable the direct generation of desired point mutations in genomic DNA without generating any double-strand breaks
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–
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, but the issue of off-target edits has limited the application of these methods. Although several previous studies have evaluated off-target mutations in genomic DNA
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Alternative Titles
Full title
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2260999963
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2260999963
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1314-0
