Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast...
Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study
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Full title
Author / Creator
Banerji, Udai, Prof , van Herpen, Carla M L, Prof , Saura, Cristina, MD , Thistlethwaite, Fiona, MD , Lord, Simon, MD , Moreno, Victor, MD , Macpherson, Iain R, MD , Boni, Valentina, MD , Rolfo, Christian, Prof , de Vries, Elisabeth G E, Prof , Rottey, Sylvie, Prof , Geenen, Jill, MD , Eskens, Ferry, MD , Gil-Martin, Marta, MD , Mommers, Ellen C, PhD , Koper, Norbert P, PhD and Aftimos, Philippe, MD
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
Subjects
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Scope and Contents
Contents
SummaryBackgroundTrastuzumab duocarmazine is a novel HER2-targeting antibody–drug conjugate comprised of trastuzumab covalently bound to a linker drug containing duocarmycin. Preclinical studies showed promising antitumour activity in various models. In this first-in-human study, we assessed the safety and activity of trastuzumab duocarmazine in pa...
Alternative Titles
Full title
Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study
Authors, Artists and Contributors
Author / Creator
van Herpen, Carla M L, Prof
Saura, Cristina, MD
Thistlethwaite, Fiona, MD
Lord, Simon, MD
Moreno, Victor, MD
Macpherson, Iain R, MD
Boni, Valentina, MD
Rolfo, Christian, Prof
de Vries, Elisabeth G E, Prof
Rottey, Sylvie, Prof
Geenen, Jill, MD
Eskens, Ferry, MD
Gil-Martin, Marta, MD
Mommers, Ellen C, PhD
Koper, Norbert P, PhD
Aftimos, Philippe, MD
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2266274278
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2266274278
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(19)30328-6
