CK2[alpha] phosphorylates BMAL1 to regulate the mammalian clock
CK2[alpha] phosphorylates BMAL1 to regulate the mammalian clock
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New York: Nature Publishing Group
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English
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New York: Nature Publishing Group
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Clock proteins govern circadian physiology and their function is regulated by various mechanisms. Here we demonstrate that Casein kinase (CK)-2alpha phosphorylates the core circadian regulator BMAL1. Gene silencing of CK2alpha or mutation of the highly conserved CK2-phosphorylation site in BMAL1, Ser90, result in impaired nuclear BMAL1 accumulation...
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Full title
CK2[alpha] phosphorylates BMAL1 to regulate the mammalian clock
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TN_cdi_proquest_journals_228293418
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_228293418
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1578
