Anti‐ BDCA 2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc‐dependen...
Anti‐ BDCA 2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc‐dependent and Fc‐independent mechanisms
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Publisher
Frankfurt: EMBO Press
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Language
English
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Publisher
Frankfurt: EMBO Press
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Contents
Type I interferons (IFN‐I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the secretion of IFN‐I from pDCs. BDCA2 is a pDC‐specific receptor that, when engaged, inhibits the production of IFN‐I...
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Full title
Anti‐ BDCA 2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc‐dependent and Fc‐independent mechanisms
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TN_cdi_proquest_journals_2290033530
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2290033530
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201404719
