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Altered synaptic ingestion by human microglia in Alzheimer's disease

Altered synaptic ingestion by human microglia in Alzheimer's disease

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2301702388

Altered synaptic ingestion by human microglia in Alzheimer's disease

About this item

Full title

Altered synaptic ingestion by human microglia in Alzheimer's disease

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2019-10

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

Synapse loss correlates strongly with cognitive decline in Alzheimer's disease, but the mechanisms underpinning this phenomenon remain unclear. Recent evidence from mouse models points to microglial cells as mediators of synapse removal, and human genetic evidence implicates microglia in disease risk. Here we demonstrate that microglia from human p...

Alternative Titles

Full title

Altered synaptic ingestion by human microglia in Alzheimer's disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2301702388

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2301702388

Other Identifiers

DOI

10.1101/795930