Synthetic lethality as an engine for cancer drug target discovery
Synthetic lethality as an engine for cancer drug target discovery
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The first wave of genetically targeted therapies for cancer focused on drugging gene products that are recurrently mutated in specific cancer types. However, mutational analysis of tumours has largely been exhausted as a strategy for the identification of new cancer targets that are druggable with conventional approaches. Furthermore, some known ge...
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Full title
Synthetic lethality as an engine for cancer drug target discovery
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TN_cdi_proquest_journals_2333915778
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2333915778
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ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/s41573-019-0046-z
