GPCR-mediated clearance of tau in post-synaptic compartments attenuates tau pathology in vivo
GPCR-mediated clearance of tau in post-synaptic compartments attenuates tau pathology in vivo
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Accumulation of pathological tau in synapses has been identified as an early pathogenic event in AD and correlates strongly with cognitive decline in patients with AD. Tau is a cytosolic, axonal protein. However, in the disease condition, tau accumulates in post-synaptic compartments and pre-synaptic terminals, either due to missorting within neuro...
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Full title
GPCR-mediated clearance of tau in post-synaptic compartments attenuates tau pathology in vivo
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TN_cdi_proquest_journals_2343851386
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2343851386
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E-ISSN
2692-8205
DOI
10.1101/2020.01.21.914135
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https://www.proquest.com/docview/2343851386?pq-origsite=primo&accountid=13902
