Clustering of CD3ζ is sufficient to initiate T cell receptor signaling
Clustering of CD3ζ is sufficient to initiate T cell receptor signaling
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Author / Creator
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
T cell activation is initiated when ligand binding to the T cell receptor (TCR) triggers intracellular phosphorylation of the TCR-CD3 complex. However, it remains unknown how biophysical properties of TCR engagement result in biochemical phosphorylation events. Here, we constructed an optogenetic tool that induces spatial clustering of CD3ζ chains...
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Full title
Clustering of CD3ζ is sufficient to initiate T cell receptor signaling
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TN_cdi_proquest_journals_2358123911
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2358123911
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E-ISSN
2692-8205
DOI
10.1101/2020.02.17.953463
How to access this item
https://www.proquest.com/docview/2358123911?pq-origsite=primo&accountid=13902
