Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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The oral delivery of bioactive peptides and proteins is prevented by the intestinal epithelial barrier, in which intercellular tight junction complexes block the uptake of macromolecules. Here we show that anionic nanoparticles induce tight junction relaxation, increasing intestinal permeability and enabling the oral delivery of proteins. This perm...
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Full title
Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability
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TN_cdi_proquest_journals_2377660954
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2377660954
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ISSN
2157-846X
E-ISSN
2157-846X
DOI
10.1038/s41551-019-0465-5
