Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimension...
Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction
About this item
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Author / Creator
Yun, Haiyang , Vohra, Shabana , Mupo, Annalisa , Giotopoulos, George , Sasca, Daniel , Horton, Sarah J , Agrawal-Singh, Shuchi , Meduri, Eshwar , Basheer, Faisal , Marando, Ludovica , Gozdecka, Malgorzata , Dovey, Oliver M , Castillo-Venzor, Aracely , Wang, Xiaonan , Gallipoli, Paolo , Mueller-Tidow, Carsten , Osborne, Cameron S , Vassiliou, George S and Huntly, Brian J P
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
Altered transcription is a cardinal feature of acute myeloid leukemia (AML), however, exactly how mutations synergize to remodel the epigenetic landscape and rewire 3-Dimensional (3-D) DNA topology is unknown. Here we apply an integrated genomic approach to a murine allelic series that models the two most common mutations in AML, Flt3-ITD and Npm1c...
Alternative Titles
Full title
Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction
Authors, Artists and Contributors
Author / Creator
Vohra, Shabana
Mupo, Annalisa
Giotopoulos, George
Sasca, Daniel
Horton, Sarah J
Agrawal-Singh, Shuchi
Meduri, Eshwar
Basheer, Faisal
Marando, Ludovica
Gozdecka, Malgorzata
Dovey, Oliver M
Castillo-Venzor, Aracely
Wang, Xiaonan
Gallipoli, Paolo
Mueller-Tidow, Carsten
Osborne, Cameron S
Vassiliou, George S
Huntly, Brian J P
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2379940411
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2379940411
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.03.20.000059
How to access this item
https://www.proquest.com/docview/2379940411?pq-origsite=primo&accountid=13902
