Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
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Author / Creator
Scott-Hewitt, Nicole J , Perrucci, Fabio , Morini, Raffaella , Erreni, Marco , Mahoney, Matthew , Witkowska, Agata , Carey, Alanna , Faggiani, Elisa , Schutz, Lisa Theresia , Mason, Sydney , Tamborini, Matteo , Passoni, Lorena , Filipello, Fabia , Jahn, Reinhard , Stevens, Beth and Matteoli, Michela
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Neuronal circuits assembly requires the fine equilibrium between synapse formation and elimination. Microglia, through the elimination of supernumerary synapses, have an established role in this process. While the microglial receptor TREM2 and the soluble complement proteins C1q and C3 are recognized key players in this process, the neuronal molecu...
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Full title
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
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TN_cdi_proquest_journals_2394617615
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2394617615
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E-ISSN
2692-8205
DOI
10.1101/2020.04.24.059584
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https://www.proquest.com/docview/2394617615?pq-origsite=primo&accountid=13902
