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Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2400132867

Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

About this item

Full title

Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2020-05

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

The PRC2 (Polycomb repressive complex 2) complex is a multi-component histone H3K27 methyltransferase, best known for silencing Hox genes during embryonic development. The Polycomb-like proteins PHF1, MTF2 and PHF19 are critical components of PRC2 by stimulating its catalytic activity in embryonic stem (ES) cells. The Tudor domains of PHF1/19 have...

Alternative Titles

Full title

Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2400132867

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2400132867

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.05.08.085233