FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis
FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis
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Gao, Lei , Su, Cong , Du, Xiaoxia , Wang, Ruishan , Chen, Shuming , Zhou, Yu , Liu, Chengwei , Liu, Xiaojing , Tian, Runze , Zhang, Liyun , Xie, Kebo , Chen, She , Guo, Qianqian , Guo, Lanping , Hano, Yoshio , Shimazaki, Manabu , Minami, Atsushi , Oikawa, Hideaki , Huang, Niu , Houk, K. N. , Huang, Luqi , Dai, Jungui and Lei, Xiaoguang
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The Diels–Alder reaction is one of the most powerful and widely used methods in synthetic chemistry for the stereospecific construction of carbon–carbon bonds. Despite the importance of Diels–Alder reactions in the biosynthesis of numerous secondary metabolites, no naturally occurring stand-alone Diels–Alderase has been demonstrated to catalyse int...
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FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis
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TN_cdi_proquest_journals_2417700028
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2417700028
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ISSN
1755-4330
E-ISSN
1755-4349
DOI
10.1038/s41557-020-0467-7