Association of tumour mutational burden with outcomes in patients with advanced solid tumours treate...
Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study
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Author / Creator
Marabelle, Aurélien, MD , Fakih, Marwan, MD , Lopez, Juanita, MB BChir , Shah, Manisha, MD , Shapira-Frommer, Ronnie, MD , Nakagawa, Kazuhiko, MD , Chung, Hyun Cheol, MD , Kindler, Hedy L, MD , Lopez-Martin, Jose A, MD , Miller, Wilson H, MD , Italiano, Antoine, MD , Kao, Steven, MD , Piha-Paul, Sarina A, MD , Delord, Jean-Pierre, MD , McWilliams, Robert R, Prof , Fabrizio, David A, PhD , Aurora-Garg, Deepti, PhD , Xu, Lei, PhD , Jin, Fan, MD , Norwood, Kevin, MD and Bang, Yung-Jue, MD
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publisher
England: Elsevier Ltd
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Scope and Contents
Contents
SummaryBackgroundTumour mutational burden (TMB) has been retrospectively correlated with response to immune checkpoint blockade. We prospectively explored the association of high tissue TMB (tTMB-high) with outcomes in ten tumour-type-specific cohorts from the phase 2 KEYNOTE-158 study, which assessed the anti-PD-1 monoclonal antibody pembrolizumab...
Alternative Titles
Full title
Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study
Authors, Artists and Contributors
Author / Creator
Fakih, Marwan, MD
Lopez, Juanita, MB BChir
Shah, Manisha, MD
Shapira-Frommer, Ronnie, MD
Nakagawa, Kazuhiko, MD
Chung, Hyun Cheol, MD
Kindler, Hedy L, MD
Lopez-Martin, Jose A, MD
Miller, Wilson H, MD
Italiano, Antoine, MD
Kao, Steven, MD
Piha-Paul, Sarina A, MD
Delord, Jean-Pierre, MD
McWilliams, Robert R, Prof
Fabrizio, David A, PhD
Aurora-Garg, Deepti, PhD
Xu, Lei, PhD
Jin, Fan, MD
Norwood, Kevin, MD
Bang, Yung-Jue, MD
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2446966114
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2446966114
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(20)30445-9
