Intermittent schedules of the oral RAF–MEK inhibitor CH5126766/VS-6766 in patients with RAS/RAF-muta...
Intermittent schedules of the oral RAF–MEK inhibitor CH5126766/VS-6766 in patients with RAS/RAF-mutant solid tumours and multiple myeloma: a single-centre, open-label, phase 1 dose-escalation and basket dose-expansion study
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Author / Creator
Guo, Christina, FRACP , Chénard-Poirier, Maxime, FRCPC , Roda, Desamparados, MD , de Miguel, Maria, MD , Harris, Samuel J, FRACP , Candilejo, Irene Moreno, MD , Sriskandarajah, Priya, PhD , Xu, Wen, FRACP , Scaranti, Mariana, MD , Constantinidou, Anastasia, MRCP , King, Jenny, MSc , Parmar, Mona, PhD , Turner, Alison J, PhD , Carreira, Suzanne, PhD , Riisnaes, Ruth, FIBMS , Finneran, Laura, MSc , Hall, Emma, Prof , Ishikawa, Yuji, PhD , Nakai, Kiyohiko, MS , Tunariu, Nina, FRCR , Basu, Bristi, FRCP , Kaiser, Martin, MD , Lopez, Juanita Suzanne, MRCP , Minchom, Anna, MD , de Bono, Johann S, Prof and Banerji, Udai, Prof
Publisher
England: Elsevier Ltd
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Language
English
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Publisher
England: Elsevier Ltd
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Contents
SummaryBackgroundCH5126766 (also known as VS-6766, and previously named RO5126766), a novel MEK-pan-RAF inhibitor, has shown antitumour activity across various solid tumours; however, its initial development was limited by toxicity. We aimed to investigate the safety and toxicity profile of intermittent dosing schedules of CH5126766, and the antitu...
Alternative Titles
Full title
Intermittent schedules of the oral RAF–MEK inhibitor CH5126766/VS-6766 in patients with RAS/RAF-mutant solid tumours and multiple myeloma: a single-centre, open-label, phase 1 dose-escalation and basket dose-expansion study
Authors, Artists and Contributors
Author / Creator
Chénard-Poirier, Maxime, FRCPC
Roda, Desamparados, MD
de Miguel, Maria, MD
Harris, Samuel J, FRACP
Candilejo, Irene Moreno, MD
Sriskandarajah, Priya, PhD
Xu, Wen, FRACP
Scaranti, Mariana, MD
Constantinidou, Anastasia, MRCP
King, Jenny, MSc
Parmar, Mona, PhD
Turner, Alison J, PhD
Carreira, Suzanne, PhD
Riisnaes, Ruth, FIBMS
Finneran, Laura, MSc
Hall, Emma, Prof
Ishikawa, Yuji, PhD
Nakai, Kiyohiko, MS
Tunariu, Nina, FRCR
Basu, Bristi, FRCP
Kaiser, Martin, MD
Lopez, Juanita Suzanne, MRCP
Minchom, Anna, MD
de Bono, Johann S, Prof
Banerji, Udai, Prof
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Record Identifier
TN_cdi_proquest_journals_2456831954
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2456831954
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(20)30464-2
