The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity
The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity
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Author / Creator
Dan Lu , Liu, Liang , Sun, Yizhe , Song, Jia , Yin, Qi , Zhang, Guangze , Qi, Fang , Hu, Zixi , Yang, Zeliang , Zhou, Zhe , Hu, Ying , Zhang, Lianhai , Ji, Jiafu , Zhao, Xuyang , Jin, Yan , McNutt, Michael A. and Yin, Yuxin
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Cancer cells subvert immune surveillance through inhibition of T cell effector function. Elucidation of the mechanism of T cell dysfunction is therefore central to cancer immunotherapy. Here, we report that dual specificity phosphatase 2 (DUSP2; also known as phosphatase of activated cells 1, PAC1) acts as an immune checkpoint in T cell antitumor i...
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Full title
The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity
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TN_cdi_proquest_journals_2475008913
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2475008913
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-019-0577-9
