Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
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Author / Creator
Gorecki, Lukas , Hepnarova, Vendula , Karasova, Jana Zdarova , Hrabinova, Martina , Courageux, Charlotte , Dias, José , Kucera, Tomas , Kobrlova, Tereza , Muckova, Lubica , Prchal, Lukas , Malinak, David , Jun, Daniel , Musilek, Kamil , Worek, Franz , Nachon, Florian , Soukup, Ondrej and Korabecny, Jan
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
To date, the only treatments developed for poisoning by organophosphorus compounds, the most toxic chemical weapons of mass destruction, have exhibited limited efficacy and versatility. The available causal antidotes are based on reactivation of the enzyme acetylcholinesterase (AChE), which is rapidly and pseudo-irreversibly inhibited by these agen...
Alternative Titles
Full title
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
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Record Identifier
TN_cdi_proquest_journals_2492787166
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2492787166
Other Identifiers
ISSN
0340-5761
E-ISSN
1432-0738
DOI
10.1007/s00204-021-02981-w
