Huntington’s disease brain-derived small RNAs recapitulate associated neuropathology in mice
Huntington’s disease brain-derived small RNAs recapitulate associated neuropathology in mice
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Author / Creator
Creus-Muncunill, Jordi , Guisado-Corcoll, Anna , Venturi, Veronica , Pantano, Lorena , Escaramís, Georgia , García de Herreros, Marta , Solaguren-Beascoa, Maria , Gámez-Valero, Ana , Navarrete, Cristina , Masana, Mercè , Llorens, Franc , Diaz-Lucena, Daniela , Pérez-Navarro, Esther and Martí, Eulàlia
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Contents
Progressive motor alterations and selective death of striatal medium spiny neurons (MSNs) are key pathological hallmarks of Huntington’s disease (HD), a neurodegenerative condition caused by a CAG trinucleotide repeat expansion in the coding region of the huntingtin (
HTT
) gene. Most research has focused on the pathogenic effects of the resu...
Alternative Titles
Full title
Huntington’s disease brain-derived small RNAs recapitulate associated neuropathology in mice
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TN_cdi_proquest_journals_2500162076
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2500162076
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-021-02272-9
