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Stiffness Regulates Intestinal Stem Cell Fate

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Stiffness Regulates Intestinal Stem Cell Fate

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2504880093

Stiffness Regulates Intestinal Stem Cell Fate

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Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

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Contents

Summary Does fibrotic gut stiffening caused by inflammatory bowel diseases (IBD) direct the fate of intestinal stem cells (ISCs)? To address this question we first developed a novel long-term culture of quasi-3D gut organoids plated on hydrogel matrix of varying stiffness. Stiffening from 0.6kPa to 9.6kPa significantly reduces Lgr5high ISCs and Ki6...

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Full title

Stiffness Regulates Intestinal Stem Cell Fate

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Record Identifier

TN_cdi_proquest_journals_2504880093

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2504880093

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E-ISSN

2692-8205

DOI

10.1101/2021.03.15.435410

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https://www.proquest.com/docview/2504880093?pq-origsite=primo&accountid=13902

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