Inhibition of peripheral VEGF signaling rapidly reduces leucocyte obstructions in brain capillaries...
Inhibition of peripheral VEGF signaling rapidly reduces leucocyte obstructions in brain capillaries and increases cortical blood flow in an Alzheimer’s disease mouse model
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Abstract Increased incidence of stalled capillary blood flow caused by adhesion of leucocytes to the brain microvascular endothelium leads to a 17% reduction of cerebral blood flow (CBF) and exacerbates short-term memory loss in multiple mouse models of Alzheimer’s disease (AD). Here, we report that Vascular Endothelial Growth Factor (VEGF) signali...
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Inhibition of peripheral VEGF signaling rapidly reduces leucocyte obstructions in brain capillaries and increases cortical blood flow in an Alzheimer’s disease mouse model
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TN_cdi_proquest_journals_2504969135
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2504969135
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2692-8205
DOI
10.1101/2021.03.05.433976
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https://www.proquest.com/docview/2504969135?pq-origsite=primo&accountid=13902
