MYC promotes immune-suppression in TNBC via inhibition of IFN signaling
MYC promotes immune-suppression in TNBC via inhibition of IFN signaling
About this item
Full title
Author / Creator
Zimmerli, Dario , Brambillasca, Chiara S , Talens, Francien , Bhin, Jinhyuk , Bhattacharya, Arkajyoti , Joosten, Stacey Ep , Da Silva, Ana Moises , Wellenstein, Max D , Kersten, Kelly , De Boo, Mart , Roorda, Maurits , Henneman, Linda , De Bruijn, Roebi , Annunziato, Stefano , Van Der Burg, Eline , Anne Paulien Drenth , Lutz, Catrin , Van De Ven, Marieke , Wessels, Lodewyk , De Visser, Karin , Zwart, Wilbert , Fehrmann, Rudolf Sn , Marcel Atm Van Vugt and Jonkers, Jos
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Abstract Immune checkpoint inhibitor (ICI) treatment has thus far shown limited efficacy in triple-negative breast cancer (TNBC) patients, presumably due to sparse or unresponsive tumor-infiltrating lymphocytes. We reveal a strong correlation between MYC expression and loss of immune signatures in human TNBC. In mouse models of BRCA1-proficient and...
Alternative Titles
Full title
MYC promotes immune-suppression in TNBC via inhibition of IFN signaling
Authors, Artists and Contributors
Author / Creator
Brambillasca, Chiara S
Talens, Francien
Bhin, Jinhyuk
Bhattacharya, Arkajyoti
Joosten, Stacey Ep
Da Silva, Ana Moises
Wellenstein, Max D
Kersten, Kelly
De Boo, Mart
Roorda, Maurits
Henneman, Linda
De Bruijn, Roebi
Annunziato, Stefano
Van Der Burg, Eline
Anne Paulien Drenth
Lutz, Catrin
Van De Ven, Marieke
Wessels, Lodewyk
De Visser, Karin
Zwart, Wilbert
Fehrmann, Rudolf Sn
Marcel Atm Van Vugt
Jonkers, Jos
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2505394521
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2505394521
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2021.02.24.432659
How to access this item
https://www.proquest.com/docview/2505394521?pq-origsite=primo&accountid=13902
