Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19
About this item
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Author / Creator
Boras, Britton , Jones, Rhys M , Anson, Brandon J , Arenson, Dan , Aschenbrenner, Lisa , Bakowski, Malina A , Beutler, Nathan , Binder, Joseph , Chen, Emily , Eng, Heather , Hammond, Holly , Hammond, Jennifer , Haupt, Robert E , Hoffman, Robert , Kadar, Eugene P , Kania, Rob , Kimoto, Emi , Kirkpatrick, Melanie G , Lanyon, Lorraine , Lendy, Emma K , Lillis, Jonathan R , Logue, James , Luthra, Suman A , Ma, Chunlong , Mason, Stephen W , Mcgrath, Marisa E , Noell, Stephen , Obach, R Scott , Matthew N O’brien , Rebecca O’connor , Ogilvie, Kevin , Owen, Dafydd , Pettersson, Martin , Reese, Matthew R , Rogers, Thomas F , Rossulek, Michelle I , Sathish, Jean G , Shirai, Norimitsu , Steppan, Claire , Ticehurst, Martyn , Updyke, Lawrence W , Weston, Stuart , Zhu, Yuao , Wang, Jun , Chatterjee, Arnab K , Mesecar, Andrew D , Frieman, Matthew B , Anderson, Annaliesa S and Allerton, Charlotte
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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More information
Scope and Contents
Contents
Abstract COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs. The designed phosphate prodrug PF-07304814 is metabolized to PF-00835321 which is a potent inhibitor in vitro of the coronavirus family 3CL p...
Alternative Titles
Full title
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19
Authors, Artists and Contributors
Author / Creator
Jones, Rhys M
Anson, Brandon J
Arenson, Dan
Aschenbrenner, Lisa
Bakowski, Malina A
Beutler, Nathan
Binder, Joseph
Chen, Emily
Eng, Heather
Hammond, Holly
Hammond, Jennifer
Haupt, Robert E
Hoffman, Robert
Kadar, Eugene P
Kania, Rob
Kimoto, Emi
Kirkpatrick, Melanie G
Lanyon, Lorraine
Lendy, Emma K
Lillis, Jonathan R
Logue, James
Luthra, Suman A
Ma, Chunlong
Mason, Stephen W
Mcgrath, Marisa E
Noell, Stephen
Obach, R Scott
Matthew N O’brien
Rebecca O’connor
Ogilvie, Kevin
Owen, Dafydd
Pettersson, Martin
Reese, Matthew R
Rogers, Thomas F
Rossulek, Michelle I
Sathish, Jean G
Shirai, Norimitsu
Steppan, Claire
Ticehurst, Martyn
Updyke, Lawrence W
Weston, Stuart
Zhu, Yuao
Wang, Jun
Chatterjee, Arnab K
Mesecar, Andrew D
Frieman, Matthew B
Anderson, Annaliesa S
Allerton, Charlotte
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2506311419
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2506311419
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.09.12.293498
How to access this item
https://www.proquest.com/docview/2506311419?pq-origsite=primo&accountid=13902
