The Synergism Between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloi...
The Synergism Between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia
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Gaidano, Valentina , Houshmand, Mohammad , Vitale, Nicoletta , Carrà, Giovanna , Morotti, Alessandro , Tenace, Valerio , Rapelli, Stefania , Sainas, Stefano , Agnese Chiara Pippione , Giorgis, Marta , Boschi, Donatella , Marco Lucio Lolli , Cignetti, Alessandro , Saglio, Giuseppe and Circosta, Paola
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Abstract Background Dihydroorotate Dehydrogenase (DHODH) is a key enzyme of the de novo pyrimidine biosynthesis, whose inhibition was recently found to induce differentiation and apoptosis in acute myeloid leukemia (AML). DHODH inhibitors were previously investigated in solid tumors, where they showed promising antiproliferative activity, both in v...
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The Synergism Between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia
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TN_cdi_proquest_journals_2507951169
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2507951169
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2692-8205
DOI
10.1101/2020.10.10.334631
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https://www.proquest.com/docview/2507951169?pq-origsite=primo&accountid=13902
