Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin
Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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English
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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ABSTRACT Neural tube defects (NTDs) are the second most common structural birth defects. Senescence, a state of permanent cell cyle arrest, only occurs after neural tube closure. Maternal diabetes-induced NTDs, severe diabetic complications leading to infant mortality or lifelong morbidity, may be linked to premature senescence. Here we report that...
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Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin
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TN_cdi_proquest_journals_2508164301
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508164301
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E-ISSN
2692-8205
DOI
10.1101/2020.09.18.303222
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https://www.proquest.com/docview/2508164301?pq-origsite=primo&accountid=13902