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Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508164301

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin

About this item

Full title

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

Journal title

bioRxiv, 2020-09

Language

English

Formats

Publication information

Publisher

Cold Spring Harbor: Cold Spring Harbor Laboratory Press

More information

Scope and Contents

Contents

ABSTRACT Neural tube defects (NTDs) are the second most common structural birth defects. Senescence, a state of permanent cell cyle arrest, only occurs after neural tube closure. Maternal diabetes-induced NTDs, severe diabetic complications leading to infant mortality or lifelong morbidity, may be linked to premature senescence. Here we report that...

Alternative Titles

Full title

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2508164301

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2508164301

Other Identifiers

E-ISSN

2692-8205

DOI

10.1101/2020.09.18.303222