A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception wit...
A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects
About this item
Full title
Author / Creator
Chakraborty, Soumen , Diberto, Jeffrey F , Abdelfattah Faouzi , Bernhard, Sarah M , Gutridge, Anna M , Ramsey, Steven , Zhou, Yuchen , Provasi, Davide , Nuthikattu, Nitin , Jilakara, Rahul , Nelson, Melissa , Asher, Wesley B , Eans, Shainnel O , Wilson, Lisa L , Chintala, Satyanarayana M , Filizola, Marta , Van Rijn, Richard M , Margolis, Elyssa B , Roth, Bryan L , Mclaughlin, Jay P , Javitch, Jonathan A , Che, Tao and Majumdar, Susruta
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Dried kratom leaves are anecdotally used for the treatment of pain, opioid dependence, and alcohol use disorder. We have previously shown that kratom and its natural products (mitragynine) and semi-synthetic analogs (7-hydroxy mitragynine (7OH) and mitragynine pseudoindoxyl) are mu opioid receptor (MOR) agonists that show minimal beta-arrestin2 rec...
Alternative Titles
Full title
A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects
Authors, Artists and Contributors
Author / Creator
Diberto, Jeffrey F
Abdelfattah Faouzi
Bernhard, Sarah M
Gutridge, Anna M
Ramsey, Steven
Zhou, Yuchen
Provasi, Davide
Nuthikattu, Nitin
Jilakara, Rahul
Nelson, Melissa
Asher, Wesley B
Eans, Shainnel O
Wilson, Lisa L
Chintala, Satyanarayana M
Filizola, Marta
Van Rijn, Richard M
Margolis, Elyssa B
Roth, Bryan L
Mclaughlin, Jay P
Javitch, Jonathan A
Che, Tao
Majumdar, Susruta
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2516612036
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2516612036
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2021.04.22.440994
How to access this item
https://www.proquest.com/docview/2516612036?pq-origsite=primo&accountid=13902
