Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational...
Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19
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Author / Creator
Thurner, Lorenz , Fadle, Natalie , Bewarder, Moritz , Kos, Igor , Regitz, Evi , Cetin, Onur , Thurner, Bernhard , Fischer, Yvan , Rixecker, Torben , Preuss, Klaus-Dieter , Schormann, Claudia , Neumann, Frank , Hartmann, Sylvia , Bock, Theresa , Kaddu-Mulindwa, Dominic , Birgit Bette , Bittenbring, Joerg Thomas , Christofyllakis, Konstantinos , Bick, Angelika , Lesan, Vadim , Abdi, Zanir , Mang, Sebastian , Becker, Andre , Metz, Carlos , Seiler, Frederik , Lehmann, Johannes , Agne, Philipp , Adams, Thomas , Link, Andreas , Werner, Christian , Thiel-Bodenstaff, Angela , Reichert, Matthias , Danziger, Guy , Papan, Cihan , Pilch, Jan , Pfuhl, Thorsten , Wuchter, Patrick , Herr, Christian , Lohse, Stefan , Schrezenmeier, Hubert , Boehm, Michael , Langer, Frank , Gaebelein, Gereon , Friesenhahn-Ochs, Bettina , Lammert, Frank , Koerper, Sixten , Rissland, Juergen , Stilgenbauer, Stephan , Lensch, Christian , Kessel, Christoph , Foell, Dirk , Bals, Robert , Becker, Soeren L , Smola, Sigrun , Krawczyk, Marcin and Lepper, Philipp
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
Hyperinflammation is frequently observed in patients with severe COVID-19. Inadequate and defective IFN type I responses against SARS-CoV-2, associated with autoantibodies in a proportion of patients, lead to severe courses of disease. In addition, hyperactive responses of the humoral immune system have been described. In the current study we inves...
Alternative Titles
Full title
Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19
Authors, Artists and Contributors
Author / Creator
Fadle, Natalie
Bewarder, Moritz
Kos, Igor
Regitz, Evi
Cetin, Onur
Thurner, Bernhard
Fischer, Yvan
Rixecker, Torben
Preuss, Klaus-Dieter
Schormann, Claudia
Neumann, Frank
Hartmann, Sylvia
Bock, Theresa
Kaddu-Mulindwa, Dominic
Birgit Bette
Bittenbring, Joerg Thomas
Christofyllakis, Konstantinos
Bick, Angelika
Lesan, Vadim
Abdi, Zanir
Mang, Sebastian
Becker, Andre
Metz, Carlos
Seiler, Frederik
Lehmann, Johannes
Agne, Philipp
Adams, Thomas
Link, Andreas
Werner, Christian
Thiel-Bodenstaff, Angela
Reichert, Matthias
Danziger, Guy
Papan, Cihan
Pilch, Jan
Pfuhl, Thorsten
Wuchter, Patrick
Herr, Christian
Lohse, Stefan
Schrezenmeier, Hubert
Boehm, Michael
Langer, Frank
Gaebelein, Gereon
Friesenhahn-Ochs, Bettina
Lammert, Frank
Koerper, Sixten
Rissland, Juergen
Stilgenbauer, Stephan
Lensch, Christian
Kessel, Christoph
Foell, Dirk
Bals, Robert
Becker, Soeren L
Smola, Sigrun
Krawczyk, Marcin
Lepper, Philipp
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2518566811
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2518566811
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2021.04.23.441188
How to access this item
https://www.proquest.com/docview/2518566811?pq-origsite=primo&accountid=13902
